tert-butyl N-methyl-N-(3-oxopropyl)carbamate → 1-{2-[{6-[(2-{3-([tert-Butoxycarbonyl)(methyl)amino]propyl}-1,2,3,4-tetrahydroisoquinolin-6-yl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

Participants

Reaction Steps

The compound (47 mg, 78.6 μmol) obtained in Example 63b and tert-butyl methyl(3-oxopropyl)carbamate (Bioorg. Med. Chem., 12, 19, 2004, 5147-5160) (18 mg, 94.3 μmol) were used to give the title compound (48 mg; yield, 79%) as a colorless oily substance according to the method described in Example 41a.

Provenance & Evidence