Methanol → HCID 66671605, compound

Participants

Reaction Steps

The compound (460 mg, 0.598 mmol) obtained in Example 78b was dissolved in 1,4-dioxane (6 mL), a 4 N hydrochloric acid-dioxane solution (1.49 mL, 5.98 mmol) and methanol (1 mL) were added under ice cooling, and the mixture was stirred at room temperature for 5.5 hours. After the reaction was completed, the solvent was evaporated under reduced pressure to give crude 1-(2-{methyl[6-(methyl{-4-[4-(methylamino)butanoyl]benzyl}amino)hexanoyl]amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate trihydrochloride. The resulting crude product was used to give the title compound (101 mg; yield, 26%) as a white solid according to the method described in Example 11e.

Provenance & Evidence