1-{2-[Methyl(6-oxohexanoyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate → HCID 66671620, compound

HRID 446577Notes

Reaction equation

HRID 446577 reaction equation
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([N:8]([CH3:21])[CH2:9][CH2:10][CH2:11][N:12]([CH3:20])[C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:7])=[C:4]([Cl:24])[CH:3]=1.[C:25]1([C:53]2[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=2)[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[NH:31][C:32](=[O:52])[O:33][CH:34]1[CH2:39][CH2:38][N:37]([CH2:40][CH2:41][N:42]([CH3:51])[C:43](=[O:50])[CH2:44][CH2:45][CH2:46][CH2:47][CH:48]=O)[CH2:36][CH2:35]1>>[C:25]1([C:53]2[CH:54]=[CH:55][CH:56]=[CH:57][CH:58]=2)[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[NH:31][C:32](=[O:52])[O:33][CH:34]1[CH2:39][CH2:38][N:37]([CH2:40][CH2:41][N:42]([C:43](=[O:50])[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][NH:1][C:2]2[CH:23]=[CH:22][C:5]([C:6](=[O:7])[N:8]([CH2:9][CH2:10][CH2:11][N:12]([C:13]([O:14][C:15]([CH3:18])([CH3:16])[CH3:17])=[O:19])[CH3:20])[CH3:21])=[C:4]([Cl:24])[CH:3]=2)[CH3:51])[CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 867619011-{2-[Methyl(6-oxohexanoyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamateHCID 86761911HCID 86761911, compound

Product 1

HCID 66671620HCID 66671620, compoundYield 59%

Procedure

The compound (149 mg, 0.420 mmol) obtained in Example 85a and the compound (163 mg, 0.351 mmol) obtained in Example 4g were used to give the title compound (166 mg; yield, 59%) as a white solid according to the method described in Example 18b.

Sources & evidence

ORD record
ord-a65f962a65f042808fb586522368da8d
Source dataset
uspto-grants-2013_07
Patent number
US08476253B2

Reaction notes

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