HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → tert-Butyl methyl[2-(methyl{[3-methyl-5-(methylamino)thiophen-2-yl]carbonyl}amino)ethyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | tert-Butyl {5-[{2-([tert-butoxycarbonyl)(methyl)amino]ethyl}(methyl)carbamoyl]-4-methylthiophen-2-yl}methylcarbamate | HCID 86663472 | — |
| Product | tert-Butyl methyl[2-(methyl{[3-methyl-5-(methylamino)thiophen-2-yl]carbonyl}amino)ethyl]carbamate | HCID 86663473 | 99% |
Reaction Steps
The compound (418 mg, 0.947 mmol) obtained in Example 90a, triethylamine (0.658 mL, 4.74 mmol) and di-tert-butyl dicarbonate (248 mg, 1.14 mmol) were used to give the title compound (319 mg; yield, 99%) as a yellow oily substance according to the method described in Example 89c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476253B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-b0fb8a4ddaf540249b643da6edeccdeb |
| Source note | uspto-grants-2013_07 |