HCID 86663417, compound → HCID 86663475, compound

HRID 446595Notes

Reaction equation

CS(O[CH2:6][CH2:7][C@:8]1([C:29]2[CH:34]=[CH:33][C:32]([F:35])=[C:31]([Br:36])[CH:30]=2)[O:12][CH2:11][N:10]([C:13](=[O:28])[C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[C:16]([C:24]([F:27])([F:26])[F:25])[CH:15]=2)[CH2:9]1)(=O)=O.[NH:37]1[CH2:42][CH2:41][C:40]2([C:50]3[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=3)[CH2:44][C@@H:43]2[O:51][CH2:52][C:53]([O:55][CH2:56][CH3:57])=[O:54])[CH2:39][CH2:38]1>>[F:23][C:20]([F:21])([F:22])[C:18]1[CH:19]=[C:14]([CH:15]=[C:16]([C:24]([F:25])([F:27])[F:26])[CH:17]=1)[C:13]([N:10]1[CH2:9][C@@:8]([CH2:7][CH2:6][N:37]2[CH2:42][CH2:41][C:40]3([C:50]4[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=4)[CH2:44][C@@H:43]3[O:51][CH2:52][C:53]([O:55][CH2:56][CH3:57])=[O:54])[CH2:39][CH2:38]2)([C:29]2[CH:34]=[CH:33][C:32]([F:35])=[C:31]([Br:36])[CH:30]=2)[O:12][CH2:11]1)=[O:28]

Participants

Reactant 2

HCID 86663417HCID 86663417, compound

HCID 86663476HCID 86663476, compound

Product 1

HCID 86663475HCID 86663475, compoundYield 67.2%

Procedure

The compound (470 mg, 0.77 mmol) obtained in Example 91i and the compound (335.4 mg, 1.16 mmol) obtained in Example 1h were used to give the title compound (415 mg; yield, 67%) as a white solid according to the method described in Example 1i.

Sources & evidence

ORD record: ord-ae7f15c613d74bd387e8374e7fb7c451
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08476253B2

Reaction notes

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