1-(2-{Methyl[N-(4-{methyl[3-(methylamino)propyl]carbamoyl}phenyl)-beta-alanyl]amino}ethyl)piperidin-4-yl biphenyl-2-ylcarbamate → 1-{2-[(N-{4-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methy)amino]propyl}(methyl)carbamoyl]phenyl}-beta-alanyl)(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate
Reaction equation
[F:1][C:2]([F:49])([F:48])[C:3]1[CH:4]=[C:5]([CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1)[C:6]([N:8]1[CH2:12][C@@:11]([CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][C:25]3([C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29][C@@H:28]3[O:36][CH2:37][C:38](O)=[O:39])[CH2:24][CH2:23]2)([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:10][CH2:9]1)=[O:7].[C:50]1([C:90]2[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=2)[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1[NH:56][C:57](=[O:89])[O:58][CH:59]1[CH2:64][CH2:63][N:62]([CH2:65][CH2:66][N:67]([CH3:88])[C:68](=[O:87])[CH2:69][CH2:70][NH:71][C:72]2[CH:77]=[CH:76][C:75]([C:78](=[O:86])[N:79]([CH3:85])[CH2:80][CH2:81][CH2:82][NH:83][CH3:84])=[CH:74][CH:73]=2)[CH2:61][CH2:60]1>>[C:50]1([C:90]2[CH:91]=[CH:92][CH:93]=[CH:94][CH:95]=2)[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1[NH:56][C:57](=[O:89])[O:58][CH:59]1[CH2:60][CH2:61][N:62]([CH2:65][CH2:66][N:67]([C:68](=[O:87])[CH2:69][CH2:70][NH:71][C:72]2[CH:73]=[CH:74][C:75]([C:78](=[O:86])[N:79]([CH2:80][CH2:81][CH2:82][N:83]([C:38](=[O:39])[CH2:37][O:36][C@@H:28]3[C:25]4([CH2:26][CH2:27][N:22]([CH2:21][CH2:20][C@:11]5([C:13]6[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=6)[O:10][CH2:9][N:8]([C:6](=[O:7])[C:5]6[CH:41]=[C:42]([C:44]([F:45])([F:46])[F:47])[CH:43]=[C:3]([C:2]([F:49])([F:1])[F:48])[CH:4]=6)[CH2:12]5)[CH2:23][CH2:24]4)[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29]3)[CH3:84])[CH3:85])=[CH:76][CH:77]=2)[CH3:88])[CH2:63][CH2:64]1Participants
3
Reactant 2
Product 1
Procedure
The compound (119 mg, 0.17 mmol) obtained in Example 1j and the compound (98 mg, 0.16 mmol) obtained in Example 94c were used to give the title compound (130 mg; yield, 64%) as a white solid according to the method described in Example 11e.
Sources & evidence
- ORD record
- ord-efbcce36e16a490a97a6e8bf84ed6884
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08476253B2
Reaction notes
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