HRID446606

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CNCCCN(C)C(=O)c1ccc(NCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)cc1

HCID66671715

未命名化合物

结构：O=C(O)CO[C@H]1Cc2ccccc2C12CCN(CC[C@@]1(c3ccc(F)cc3)CN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CO1)CC2

HCID86663420

未命名化合物

PRODUCTS

生成物

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCNc1ccc(C(=O)N(C)CCCN(C)C(=O)CO[C@H]2Cc3ccccc3C23CCN(CC[C@@]2(c4ccc(F)cc4)CN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CO2)CC3)cc1

HCID46928442

未命名化合物

收率 64%

PROCEDURE

实验过程

The compound (119 mg, 0.17 mmol) obtained in Example 1j and the compound (98 mg, 0.16 mmol) obtained in Example 94c were used to give the title compound (130 mg; yield, 64%) as a white solid according to the method described in Example 11e.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-efbcce36e16a490a97a6e8bf84ed6884
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476253B2
来源说明: uspto-grants-2013_07

反应 SMILES

[F:1][C:2]([F:49])([F:48])[C:3]1[CH:4]=[C:5]([CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1)[C:6]([N:8]1[CH2:12][C@@:11]([CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][C:25]3([C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29][C@@H:28]3[O:36][CH2:37][C:38](O)=[O:39])[CH2:24][CH2:23]2)([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:10][CH2:9]1)=[O:7].[C:50]1([C:90]2[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=2)[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1[NH:56][C:57](=[O:89])[O:58][CH:59]1[CH2:64][CH2:63][N:62]([CH2:65][CH2:66][N:67]([CH3:88])[C:68](=[O:87])[CH2:69][CH2:70][NH:71][C:72]2[CH:77]=[CH:76][C:75]([C:78](=[O:86])[N:79]([CH3:85])[CH2:80][CH2:81][CH2:82][NH:83][CH3:84])=[CH:74][CH:73]=2)[CH2:61][CH2:60]1>>[C:50]1([C:90]2[CH:91]=[CH:92][CH:93]=[CH:94][CH:95]=2)[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1[NH:56][C:57](=[O:89])[O:58][CH:59]1[CH2:60][CH2:61][N:62]([CH2:65][CH2:66][N:67]([C:68](=[O:87])[CH2:69][CH2:70][NH:71][C:72]2[CH:73]=[CH:74][C:75]([C:78](=[O:86])[N:79]([CH2:80][CH2:81][CH2:82][N:83]([C:38](=[O:39])[CH2:37][O:36][C@@H:28]3[C:25]4([CH2:26][CH2:27][N:22]([CH2:21][CH2:20][C@:11]5([C:13]6[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=6)[O:10][CH2:9][N:8]([C:6](=[O:7])[C:5]6[CH:41]=[C:42]([C:44]([F:45])([F:46])[F:47])[CH:43]=[C:3]([C:2]([F:49])([F:1])[F:48])[CH:4]=6)[CH2:12]5)[CH2:23][CH2:24]4)[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29]3)[CH3:84])[CH3:85])=[CH:76][CH:77]=2)[CH3:88])[CH2:63][CH2:64]1