3-(Methylamino)propanoic acid, N-BOC protected → Benzyl {6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(4-{[N-(tert-butoxycarbonyl)-N-methyl-beta-alanyl](methyl)amino}phenyl)carbamate

HRID 446611Notes

Reaction equation

HRID 446611 reaction equation
[C:1]([O:5][C:6]([N:8]([CH3:14])[CH2:9][CH2:10][C:11]([OH:13])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:15]1([C:61]2[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=2)[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[NH:21][C:22]([O:24][CH:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][N:33]([CH3:60])[C:34](=[O:59])[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][N:40]([C:51]2[CH:56]=[CH:55][C:54]([NH:57][CH3:58])=[CH:53][CH:52]=2)[C:41](=[O:50])[O:42][CH2:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH2:27][CH2:26]1)=[O:23]>>[C:15]1([C:61]2[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=2)[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[NH:21][C:22]([O:24][CH:25]1[CH2:26][CH2:27][N:28]([CH2:31][CH2:32][N:33]([CH3:60])[C:34](=[O:59])[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][N:40]([C:51]2[CH:56]=[CH:55][C:54]([N:57]([C:11](=[O:13])[CH2:10][CH2:9][N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH3:14])[CH3:58])=[CH:53][CH:52]=2)[C:41](=[O:50])[O:42][CH2:43][C:44]2[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=2)[CH2:29][CH2:30]1)=[O:23]

Participants

3

Reactant 2

HCID 27609523-(Methylamino)propanoic acid, N-BOC protectedHCID 66671650HCID 66671650, compound

Product 1

HCID 66793891Benzyl {6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(4-{[N-(tert-butoxycarbonyl)-N-methyl-beta-alanyl](methyl)amino}phenyl)carbamateYield 112.2%

Procedure

N-(tert-Butoxycarbonyl)-N-methyl-β-alanine (41 mg, 0.19 mmol) and the compound (150 mg, 0.21 mmol) obtained in Example 97c were used to give the title compound (190 mg; yield, 100%) as a white solid according to the method described in Example 41a.

Sources & evidence

ORD record
ord-12c2398d6613446e8a7cfb7e548cb84f
Source dataset
uspto-grants-2013_07
Patent number
US08476253B2

Reaction notes

Loading…