HRID446612

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CNCCC(=O)N(C)c1ccc(N(CCCCCC(=O)N(C)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)C(=O)OCc2ccccc2)cc1

HCID66671493

未命名化合物

结构：O=C(O)CO[C@H]1Cc2ccccc2C12CCN(CC[C@@]1(c3ccc(F)cc3)CN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CO1)CC2

HCID86663420

未命名化合物

PRODUCTS

生成物

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCCN(C(=O)OCc1ccccc1)c1ccc(N(C)C(=O)CCN(C)C(=O)CO[C@H]2Cc3ccccc3C23CCN(CC[C@@]2(c4ccc(F)cc4)CN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CO2)CC3)cc1

HCID86663479

未命名化合物

收率 76.7%

PROCEDURE

实验过程

The compound (111 mg, 0.16 mmol) obtained in Example 1j and the compound (133 mg, 0.17 mmol) obtained in Example 97e were used to give the title compound (180 mg; yield, 73%) as a white solid according to the method described in Example 11e.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-be4a726dd30745f8adb2d29739570451
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476253B2
来源说明: uspto-grants-2013_07

反应 SMILES

[F:1][C:2]([F:49])([F:48])[C:3]1[CH:4]=[C:5]([CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1)[C:6]([N:8]1[CH2:12][C@@:11]([CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][C:25]3([C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29][C@@H:28]3[O:36][CH2:37][C:38](O)=[O:39])[CH2:24][CH2:23]2)([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:10][CH2:9]1)=[O:7].[C:50]1([C:102]2[CH:107]=[CH:106][CH:105]=[CH:104][CH:103]=2)[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1[NH:56][C:57]([O:59][CH:60]1[CH2:65][CH2:64][N:63]([CH2:66][CH2:67][N:68]([CH3:101])[C:69](=[O:100])[CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][N:75]([C:86]2[CH:91]=[CH:90][C:89]([N:92]([CH3:99])[C:93](=[O:98])[CH2:94][CH2:95][NH:96][CH3:97])=[CH:88][CH:87]=2)[C:76](=[O:85])[O:77][CH2:78][C:79]2[CH:84]=[CH:83][CH:82]=[CH:81][CH:80]=2)[CH2:62][CH2:61]1)=[O:58]>>[C:50]1([C:102]2[CH:107]=[CH:106][CH:105]=[CH:104][CH:103]=2)[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=1[NH:56][C:57]([O:59][CH:60]1[CH2:61][CH2:62][N:63]([CH2:66][CH2:67][N:68]([CH3:101])[C:69](=[O:100])[CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][N:75]([C:86]2[CH:87]=[CH:88][C:89]([N:92]([C:93](=[O:98])[CH2:94][CH2:95][N:96]([C:38](=[O:39])[CH2:37][O:36][C@@H:28]3[C:25]4([CH2:26][CH2:27][N:22]([CH2:21][CH2:20][C@:11]5([C:13]6[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=6)[O:10][CH2:9][N:8]([C:6](=[O:7])[C:5]6[CH:41]=[C:42]([C:44]([F:45])([F:46])[F:47])[CH:43]=[C:3]([C:2]([F:49])([F:1])[F:48])[CH:4]=6)[CH2:12]5)[CH2:23][CH2:24]4)[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[CH2:29]3)[CH3:97])[CH3:99])=[CH:90][CH:91]=2)[C:76](=[O:85])[O:77][CH2:78][C:79]2[CH:80]=[CH:81][CH:82]=[CH:83][CH:84]=2)[CH2:64][CH2:65]1)=[O:58]