m-Chloroperbenzoic acid → 2-((1-Nitrocyclohexyl)methyl)oxirane

HRID 446632Notes

Reaction equation

HRID 446632 reaction equation
C1C=C(Cl)C=C(C(OO)=[O:9])C=1.[CH2:12]([C:15]1([N+:21]([O-:23])=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[CH:13]=[CH2:14]>C(Cl)Cl>[N+:21]([C:15]1([CH2:12][CH:13]2[CH2:14][O:9]2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)([O-:23])=[O:22]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acid2×HCID 128119361-Allyl-1-nitrocyclohexane

Product 1

HCID 583089362-((1-Nitrocyclohexyl)methyl)oxirane

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A 1 neck 500 mL round bottom flask equipped with dropping funnel, temperature controller, nitrogen outlet, stir bar and condenser is charged with approximately 37 g of mCPBA (72% pure, 0.15 mols) and 100 mL of CH2Cl2. The reaction slurry is warmed to dissolve all the solids in CH2Cl2. Once a clear solution is obtained, 20 g (0.12 mols) of 1-allyl-1-nitrocyclohexane (11) is added slowly. After complete addition, the reaction is refluxed for 2 hrs and stirred for 48 h at room temperature. The progress of the reaction is monitored by GC. After the duration of almost 50 h, the composition of the epoxide in the reaction mixture is approximately 38.5%. Solid mCPBA that crashes out of solution is removed by gravity filtration. The organic layer is washed with 10% Na2CO3 (3×30 mL) followed by brine (3×30 mL). The organic layer is dried under MgSO4 and excess solvent stripped off under rotary evaporator. This affords 11.8 g of crude material. The retention time of the epoxide on the GC is 18.3 minutes. The presence of epoxide is confirmed by GC-MS CI. The parent ion is not detected due to the labile nature of NO2 groups. However, the fragment minus the NO2 is observed. CI GC/MS, [C9H15O]+=139.

Workup

  1. customA 1 neck 500 mL round bottom flask equipped
  2. customThe reaction
  3. temperatureslurry is warmed
  4. customOnce a clear solution is obtained
  5. additionAfter complete addition
  6. temperaturethe reaction is refluxed for 2 hrs
  7. stirringstirred for 48 h at room temperature
  8. customAfter the duration of almost 50 h
  9. customis removed by gravity filtration
  10. washThe organic layer is washed with 10% Na2CO3 (3×30 mL)
  11. customThe organic layer is dried under MgSO4
  12. customexcess solvent stripped off under rotary evaporator

Sources & evidence

ORD record
ord-5558b449541a4d038c1b51f58d7a42d2
Source dataset
uspto-grants-2013_07
Patent number
US08480800B2

Reaction notes

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