反应详情

19 ml of a 4M solution of HCl in dioxane are added to 2.3 g of 4-(2-(4-(tert-butoxycarbonyl)piperazin-1-yl)ethoxy)-2,6-bis(hydroxymethyl)pyridine in solution in 33 ml of dioxane. After 12 h at AT, the resulting precipitate is recovered by filtration on a sintered glass funnel, taken up in MeOH and then concentrated under RP, and the residue is diluted in 40 ml of an MeOH/water 1/1 mixture. The resulting solution is deposited on Mega BE-SCX, 25GM 150ML (Varian). After washing the phase with MeOH, the product of interest is eluted with a 2N solution of ammonia in methanol. The MeOH/NH3 phase is concentrated under RP. 1.6 g of 4-[2-(piperazin-1-yl)ethoxy]-2,6-bis(hydroxymethyl)pyridine are thus obtained.

1. filtrationthe resulting precipitate is recovered by filtration on a sintered glass funnel
2. concentrationconcentrated under RP
3. additionthe residue is diluted in 40 ml of an MeOH/water 1/1 mixture
4. washAfter washing the phase with MeOH
5. washthe product of interest is eluted with a 2N solution of ammonia in methanol
6. concentrationThe MeOH/NH3 phase is concentrated under RP