HCID 58293748, compound → HCID 58293830, compound

Participants

Reaction Steps

N-tert-Butyl-3-(1-(2,3-difluoro-4-vinylphenyl)-1H-tetrazol-5-yl)pyridin-2-amine (Compound 1081, 260 mg) was dissolved in 30 ml of ethyl acetate. 10% Palladium on carbon was added to the mixture and the reaction flask was charged with hydrogen (1 atm). After stirring at RT for 12 hours, the reaction was filtered through diatomaceous earth, concentrated in vacuo, and the residue purified by column chromatography (SiO2), eluting with 0-20% EtOAc/Hexane, to afford 130 mg of N-tert-Butyl-3-(1-(4-ethyl-2,3-difluorophenyl)-1H-tetrazol-5-yl)pyridin-2-amine (Compound 1082); MS (M+1)=359.4.

Provenance & Evidence