N-bromobutanimide → HCID 67027112, compound

HRID 446736Notes

Reaction equation

[C:1]([NH:5][C:6]1[C:11]([C:12]2[N:16]([C:17]3[CH:22]=[CH:21][C:20]([CH2:23][CH3:24])=[C:19]([F:25])[C:18]=3[F:26])[N:15]=[N:14][N:13]=2)=[CH:10][CH:9]=[CH:8][N:7]=1)([CH3:4])([CH3:3])[CH3:2].C1C(=O)N([Br:34])C(=O)C1>>[C:1]([NH:5][C:6]1[C:11]([C:12]2[N:16]([C:17]3[CH:22]=[CH:21][C:20]([CH2:23][CH3:24])=[C:19]([F:25])[C:18]=3[F:26])[N:15]=[N:14][N:13]=2)=[CH:10][C:9]([Br:34])=[CH:8][N:7]=1)([CH3:2])([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 67184N-bromobutanimide

HCID 58293830HCID 58293830, compound

Product 1

HCID 67027112HCID 67027112, compound

Procedure

Compound 1082 can be further reacted with NBS according to procedures analogous to those provided herein to provide N-tert-butyl-5-bromo-3-(1-(4-ethyl-2,3-difluorophenyl)-1H-tetrazol-5-yl)pyridin-2-amine (Compound 1083).

Workup

customthose provided herein

Sources & evidence

ORD record: ord-d14aaa3ec13841abb429a3a23a57c142
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08481524B2

Reaction notes

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