N-bromobutanimide → HCID 58293816, compound

Participants

Reaction Steps

Compound 1084 (200 mg, 0.54 mmol) was dissolved in 10 mL of acetonitrile. N-Bromosuccinimide (96 mg, 0.54 mmol) was added to the solution and the reaction mixture was stirred at room temperature for 30 minutes. The reaction was quenched with 1 M Na2S2O3 and the mixture extracted with ethyl acetate. The organice layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford a white solid that was purified by silica gel chromatography to afford 37 mg of N-tert-butyl-5-bromo-3-(1-(4-cyclopropyl-2,3-difluorophenyl)-1H-tetrazol-5-yl)pyridin-2-amine (Compound 1085); MS (M+1)=449.

Provenance & Evidence