1,4-Dioxane hydrochloride → HCID 67027118, compound

Participants

Reaction Steps

tert-Butyl 4-(4-(6-amino-5-(1-(2,3-difluoro-4-methylphenyl)-1H-tetrazol-5-yl)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (Compound 1102, 3.5 g, 6.511 mmol) was treated with 4.0 M HCl/dioxane (50 mL, 200.0 mmol) for 1 h at RT. The precipitate was collected by filtration and dried under vacuum to give 3-(1-(2,3-difluoro-4-methylphenyl)-1H-tetrazol-5-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine dihydrochloride salt (Compound 11, 3.3 g, 99%) as a slightly yellow solid.

Provenance & Evidence