反应详情

Compound 1103 (3.0 g, 5.419 mmol) was treated with 4 M HCl/dioxane (50 mL, 200.0 mmol) for 1 hour at RT. The solvents were removed by vacuum evaporation to give 3-(1-(2,3-difluoro-4-methoxyphenyl)-1H-tetrazol-5-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine, dihydrochloride salt (Compound 12, 2.8 g, 98%) as a slightly yellow solid.

1. customThe solvents were removed by vacuum evaporation