Acetic Acid → HCID 178477850, compound

Participants

Reaction Steps

A solution of trans-1-(4-benzo[d]isothiazol-3-yl-cyclohexyl)-8-chloro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene (35.0 mg, 0.0803 mmol), cyclobutanone (11.3 mg, 0.161 mmol) and acetic acid (0.009 ml, 0.2 mmol) in 1,2-dichloroethane (0.8 ml) was stirred at room temperature for 20 h. After addition of sodium triacetoxyborohydride (37.4 mg, 0.177 mmol) the mixture was stirred for 1 h. Addition of methanol (0.5 ml) and N-ethyl diisopropylamine (0.028 ml, 0.16 mmol) to the reaction mixture was followed by concentration in vacuo. Preparative RP-HPLC with water (0.05% formic acid)/methanol as eluent gave the title compound (27 mg, 69%) as white solid. MS m/e: 490 ([M+H]+)

Provenance & Evidence