Water → HCID 58503177, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of 4 (51.2 g, 32.5 mmol) in dioxane (600 ml) was added a solution of TFA (16.02 ml, 208 mmol) in water (200 ml) and the reaction was heated at 50° C. for 17 hours. The reaction mixture was diluted with EtOAc (800 mL) and washed with sat. aq. NaHCO3 (2×800 mL), brine (400 mL), dried over MgSO4, filtered and concentrated under vacuum to yield 5 (49.9 g, 32.5 mmol, 100% yield): MS m/z calcd for C78H82N6O24 (M+Na+) 1509.5. found 1509.3.

Provenance & Evidence