HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Acetylpyridine → 4-(Bromoacetyl)pyridine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Acetylpyridine | HCID 14282 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 4-(Bromoacetyl)pyridine hydrobromide | HCID 2776239 | 783.1% |
Reaction Steps
To a stirred solution of 1-(pyridin-4-yl)ethanone (10 g, 0.08 mol) in CCl4 (150 mL), Br2 (3.99 mL, 0.02 mol) was added dropwise at 0° C. The reaction mixture was then refluxed for 1 h, filtered, and dried in vacuo to afford 2-bromo-1-(pyridin-4-yl)ethanone hydro bromide (22 g, 94%) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481534B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-e2455dc868eb4c8cb08a8edbb4be47e4 |
| Source note | uspto-grants-2013_07 |