反应详情

To a solution of 1-(4-(benzyloxy)phenyl)ethanone (5.0 g, 0.02 mol) in MeOH (120 mL) was added a solution of Br2 (4.22 g, 0.026 mol) in MeOH (13 mL). The reaction mixture was stirred at RT for 3 h and then concentrated in vacuo. The residue was then treated with HCl (1N, 20 mL), quenched with ice, and the resulting solid precipitate was filtered and dried in vacuo to afford 1-(4-(benzyloxy)phenyl)-3-phenylpropan-1-one (6 g, 89%) as a white solid.

1. concentrationconcentrated in vacuo
2. additionThe residue was then treated with HCl (1N, 20 mL)
3. customquenched with ice
4. filtrationthe resulting solid precipitate was filtered
5. customdried in vacuo