4-(4-(benzyloxy)phenyl)-3-(4-methoxyphenyl)furan-2(5H)-one → 4-(4-hydroxyphenyl)-3-(4-methoxyphenyl)furan-2(5H)-one

Participants

Reaction Steps

To a 0° C. solution of 4-(4-(benzyloxy)phenyl)-3-(4-methoxyphenyl)furan-2(5H)-one (1.5 g, 0.004 mol) in MeOH (50 mL) was added Pd(OH)2 (150 mg, 1.068 mol) under an inert atmosphere. The reaction mixture was then stirred under a hydrogen atmosphere for 2 h at RT, filtered through a pad of Celite® and the filtrate was concentrated in vacuo to afford 4-(4-hydroxyphenyl)-3-(4-methoxyphenyl)furan-2(5H)-one (900 mg, 81%) as a solid.

Provenance & Evidence