反应详情

A solution of (6-methylpyridin-2-yl)methanol hydrochloride (1.0 g, 0.008 mol) in SOCl2 (3 mL) was stirred at RT for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude product. The crude material was azeotroped with toluene and the resulting residue was filtered and dried in vacuo to afford 2-(chloromethyl)-6-methylpyridine (800 mg, 63%) as a light brown solid.

1. concentrationThe reaction mixture was then concentrated in vacuo
2. customto obtain the crude product
3. customThe crude material was azeotroped with toluene
4. filtrationthe resulting residue was filtered
5. customdried in vacuo