HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (4-Methylpiperazin-1-yl)(piperidin-4-yl)methanone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-Dimethylethyl 4-[(4-methyl-1-piperazinyl)carbonyl]-1-piperidinecarboxylate | HCID 3961434 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (4-Methylpiperazin-1-yl)(piperidin-4-yl)methanone hydrochloride | HCID 56831934 | 54% |
Reaction Steps
A mixture of 4-(4-methyl-piperazine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester (25.8 g, 82.8 mmol), dry dioxane (500 mL) and 6.5 N hydrogen chloride in dioxane (275 mL) was stirred at room temperature overnight, then diluted with diethyl ether and stirred at 0° C. for 1 h. The precipitated crystals were filtered off, washed with diethyl ether and dried to yield 12.44 g (54%) of the title compound. Mp: 305-307° C. (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481527B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-faaea22dc72e458b92484d4749750b56 |
| Source note | uspto-grants-2013_07 |