tert-Butyl piperazine-1-carboxylate → HCID 68577687, compound

HRID 446862Notes

Reaction equation

HRID 446862 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][S:15]([C:18]1[CH:37]=[CH:36][C:21]([C:22]([NH:24][CH2:25][C:26]([N:28]2[CH2:32][CH2:31][CH2:30][C@H:29]2[C:33]([OH:35])=O)=[O:27])=[O:23])=[CH:20][CH:19]=1)(=[O:17])=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:38]([O:42][C:43]([N:45]1[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]1)=[O:44])([CH3:41])([CH3:40])[CH3:39]>>[C:38]([O:42][C:43]([N:45]1[CH2:50][CH2:49][N:48]([C:33]([C@@H:29]2[CH2:30][CH2:31][CH2:32][N:28]2[C:26](=[O:27])[CH2:25][NH:24][C:22](=[O:23])[C:21]2[CH:36]=[CH:37][C:18]([S:15](=[O:17])(=[O:16])[NH:14][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[O:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:19][CH:20]=2)=[O:35])[CH2:47][CH2:46]1)=[O:44])([CH3:41])([CH3:39])[CH3:40]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 68577185HCID 68577185, compound

Product 1

HCID 68577687HCID 68577687, compound

Procedure

The title compound was prepared from (S)-1-{2-[4-(2-phenoxy-phenylsulfamoyl)-benzoylamino]-acetyl}-pyrrolidine-2-carboxylic acid and piperazine-1-carboxylic acid tert-butyl ester according to the method described in Example 1.1/d. MS (EI) 714.3 (M+Na+).

Sources & evidence

ORD record
ord-e671942103a14fe6b9cc752bc7486fcd
Source dataset
uspto-grants-2013_07
Patent number
US08481527B2

Reaction notes

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