tert-Butyl piperazine-1-carboxylate → 4-[2-(2,4-Dichloro-phenoxy)-phenylsulfamoyl]-N-(2-oxo-2-piperazin-1-yl-ethyl)-benzamide hydrochloride

HRID 446880Notes

Reaction equation

HRID 446880 reaction equation
[Cl:1][C:2]1[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11][S:12]([C:15]1[CH:27]=[CH:26][C:18]([C:19]([NH:21][CH2:22][C:23](O)=[O:24])=[O:20])=[CH:17][CH:16]=1)(=[O:14])=[O:13].C(OC([N:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)=O)(C)(C)C>>[ClH:1].[Cl:1][C:2]1[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11][S:12]([C:15]1[CH:27]=[CH:26][C:18]([C:19]([NH:21][CH2:22][C:23](=[O:24])[N:40]2[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]2)=[O:20])=[CH:17][CH:16]=1)(=[O:13])=[O:14]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 68493493{4-[2-(2,4-Dichloro-phenoxy)-phenylsulfamoyl]-benzoylamino}-acetic acid

Product 1

HCID 249874504-[2-(2,4-Dichloro-phenoxy)-phenylsulfamoyl]-N-(2-oxo-2-piperazin-1-yl-ethyl)-benzamide hydrochloride

Procedure

The title compound was prepared from {4-[2-(2,4-dichloro-phenoxy)-phenylsulfamoyl]-benzoylamino}-acetic acid (Example 1.1/e) and piperazine-1-carboxylic acid tert-butyl ester (Aldrich) according to the method described in Example 11.1. MS (EI) 564.2 (MH+).

Sources & evidence

ORD record
ord-0b773bf7ea83463dbaeaaaaeb9a4d25f
Source dataset
uspto-grants-2013_07
Patent number
US08481527B2

Reaction notes

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