Tert-butyl 1,4-diazepane-1-carboxylate → N-(2-[1,4]Diazepan-1-yl-2-oxo-ethyl)-4-[2-(2,4-dichloro-phenoxy)-phenylsulfamoyl]-benzamide hydrochloride

HRID 446881Notes

Reaction equation

HRID 446881 reaction equation
[Cl:1][C:2]1[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11][S:12]([C:15]1[CH:27]=[CH:26][C:18]([C:19]([NH:21][CH2:22][C:23]([OH:25])=O)=[O:20])=[CH:17][CH:16]=1)(=[O:14])=[O:13].C(OC([N:40]1[CH2:46][CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)=O)(C)(C)C>>[ClH:1].[N:40]1([C:23](=[O:25])[CH2:22][NH:21][C:19](=[O:20])[C:18]2[CH:17]=[CH:16][C:15]([S:12](=[O:14])(=[O:13])[NH:11][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[O:4][C:3]3[CH:28]=[CH:29][C:30]([Cl:32])=[CH:31][C:2]=3[Cl:1])=[CH:27][CH:26]=2)[CH2:46][CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1

Participants

3

Reactant 2

HCID 2756058Tert-butyl 1,4-diazepane-1-carboxylateHCID 68493493{4-[2-(2,4-Dichloro-phenoxy)-phenylsulfamoyl]-benzoylamino}-acetic acid

Product 1

HCID 24987823N-(2-[1,4]Diazepan-1-yl-2-oxo-ethyl)-4-[2-(2,4-dichloro-phenoxy)-phenylsulfamoyl]-benzamide hydrochloride

Procedure

The title compound was prepared from {4-[2-(2,4-dichloro-phenoxy)-phenylsulfamoyl]-benzoylamino}-acetic acid (Example 1.1/e) and [1,4]diazepane-1-carboxylic acid tert-butyl ester (Fluka) according to the method described in Example 11.1. MS (EI) 578.2 (MH+).

Sources & evidence

ORD record
ord-0474cb8bc3a04362bfad75bc62f09a18
Source dataset
uspto-grants-2013_07
Patent number
US08481527B2

Reaction notes

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