4-(N-Boc-amino)piperidine → N-[2-(4-Amino-piperidin-1-yl)-2-oxo-ethyl]-4-[2-(2,4-dichloro-benzoyl)-phenylsulfamoyl]-benzamide hydrochloride

HRID 446885Notes

Reaction equation

HRID 446885 reaction equation
[Cl:1][C:2]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][S:13]([C:16]1[CH:28]=[CH:27][C:19]([C:20]([NH:22][CH2:23][C:24]([OH:26])=O)=[O:21])=[CH:18][CH:17]=1)(=[O:15])=[O:14])=[O:5].C(OC(=O)[NH:40][CH:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)(C)(C)C>>[ClH:1].[NH2:40][CH:41]1[CH2:46][CH2:45][N:44]([C:24](=[O:26])[CH2:23][NH:22][C:20](=[O:21])[C:19]2[CH:18]=[CH:17][C:16]([S:13](=[O:15])(=[O:14])[NH:12][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[C:4](=[O:5])[C:3]3[CH:29]=[CH:30][C:31]([Cl:33])=[CH:32][C:2]=3[Cl:1])=[CH:28][CH:27]=2)[CH2:43][CH2:42]1

Participants

3

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 68492509{4-[2-(2,4-Dichloro-benzoyl)-phenylsulfamoyl]-benzoylamino}-acetic acid

Product 1

HCID 68578917N-[2-(4-Amino-piperidin-1-yl)-2-oxo-ethyl]-4-[2-(2,4-dichloro-benzoyl)-phenylsulfamoyl]-benzamide hydrochloride

Procedure

The title compound was prepared from {4-[2-(2,4-dichloro-benzoyl)-phenylsulfamoyl]-benzoylamino}-acetic acid (Example 6.1/c)) and piperidin-4-yl-carbamic acid tert-butyl ester (Aldrich) according to the method described in Example 11.1. MS (EI) 589.3 (MH+).

Sources & evidence

ORD record
ord-d0aca012b80e4b23afd7a82735bf3e16
Source dataset
uspto-grants-2013_07
Patent number
US08481527B2

Reaction notes

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