反应详情

(Step 7-i) To a solution of 5-bromo-2-chloropyridine-3-carbonitrile (2 g, 9.22 mmol) in 30 mL n-butanol was added 2 mL anhydrous hydrazine. The reaction mixture was heated under reflux for 14 hrs and allowed to cool to room temperature. The solvent was removed by evaporation and the residue was poured into a saturated NaHCO3 solution. The resulting precipitate was collected and washed with water. After drying in vacuo, the product, 5-bromo-1H-pyrazolo[3,4-b]pyridin-3-amine, can be used directly without further purification.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 14 hrs
3. customThe solvent was removed by evaporation
4. additionthe residue was poured into a saturated NaHCO3 solution
5. customThe resulting precipitate was collected
6. washwashed with water
7. customAfter drying in vacuo
8. customthe product, 5-bromo-1H-pyrazolo[3,4-b]pyridin-3-amine, can be used directly without further purification