反应详情

A solution of 18 (0.4 g, 0.64 mmol) in MeOH (20 mL) was treated with 10% Pd/C (wet, 216 mg) and reduced under an H2 atmosphere (50 psi) using a Parr apparatus. After 1.5 h, the mixture was filtered through a nylon filter cartridge and the solids were washed with MeOH. The filtrate was concentrated to afford 19 (0.31 g) as an orange-colored oil which was used without further purification. Mass spectrum, m/z [495.4] (M+H)+.

1. filtrationthe mixture was filtered through a nylon
2. filtrationfilter cartridge
3. washthe solids were washed with MeOH
4. concentrationThe filtrate was concentrated