Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → HCID 67216716, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Hexahydro-pyrrolo[3,2-b]pyrrole-1,3,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 3-methyl ester | HCID 67280928 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | HCID 67216716 | HCID 67216716 | 101.1% |
반응 단계
A solution of 14 (923 mg, 2.28 mmol) in MeOH (20 mL) was treated with 1M NaOH (7.8 mL) at ambient temperature. After 1.5 h, the solution was concentrated and diluted with EtOAc and 1M HCl. The layers were separated and the aqueous phase was extracted with EtOAc. The combined organic extracts were washed successively with 1M HCl, and brine, dried over anhydrous Na2SO4, filtered and concentrated to afford 36 as a yellow-colored foam (900 mg) which was used without further purification. Mass spectrum, m/z [391.4] (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08481495B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-bc57a267667f48b19f8b955836ad8502 |
| 출처 메모 | uspto-grants-2013_07 |