反应详情

温度

60 °C

To an ice-cold solution of 2,6-dibromo-4-nitro-aniline (100 g, 0.34 mol) in 1.50 L of ethanol was added dropwise conc. H2SO4 (116 ml, 2.15 mol) over 30-45 min with constant stirring. The reaction mixture was heated to 60° C. and sodium nitrite (72 g, 1.09 mol) was added to the reaction mixture portion wise. The resulting yellow colored reaction mixture was heated slowly to 90° C. and refluxed for 2 to 2.5 h. After cooling to room temperature, the mixture was poured into ice water. The reddish brown solid thus obtained was filtered, washed with water and dried to give the desired compound as a brown solid (85.0 g, 90%).

1. temperatureThe resulting yellow colored reaction mixture was heated slowly to 90° C.
2. temperaturerefluxed for 2 to 2.5 h
3. temperatureAfter cooling to room temperature
4. customThe reddish brown solid thus obtained
5. filtrationwas filtered
6. washwashed with water
7. customdried