HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 447029Generated: October 30, 2026
Ethyl isocyanate → 2-(3-Ethyl-ureido)-5-pyridin-3-yl-benzothiazole-7-carboxylic acid methyl ester
https://huagongshe.com/reaction/447029
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl isocyanate | HCID 8022 | — |
| Reactant | 2-Amino-5-pyridin-3-yl-benzothiazole-7-carboxylic acid methyl ester | HCID 57813656 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(3-Ethyl-ureido)-5-pyridin-3-yl-benzothiazole-7-carboxylic acid methyl ester | HCID 57813619 | — |
Reaction Steps
A stirred mixture of 2-Amino-5-pyridin-3-yl-benzothiazole-7-carboxylic acid methyl ester (20 mg, 0.07 mmol), ethyl isocyanate (0.03 ml, 0.35 mmol) and dibutyltindiacetate (2 drops) in anhydrous 1,4-dioxane (1.5 ml) was heated by microwave irradiation in a CEM Discover reactor at 125° C. for 1 h. After cooling to ambient temperature, the 2-(3-Ethyl-ureido)-5-pyridin-3-yl-benzothiazole-7-carboxylic acid methyl ester was isolated by Preparative HPLC as a white solid (7.4 mg, 30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08481544B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-049d00827cb540ba91820c6665fe3593 |
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| Source note | uspto-grants-2013_07 |
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