反应详情

To an ice-cold solution of 2-amino-5-nitro phenol (40.0 g, 259.52 mmol) in DCM (1.0 L), was added bromine (13.38 mL, 259.52 mmol) drop wise. The resulting reaction mixture was stirred at room temperature for 45 min. After the completion of the reaction (TLC monitoring), water was added and extracted with EtOAc (3×1.0 L). The combined organics was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude (55.0 g, 92%) was carried forward to the next step without further purification.

1. customThe resulting reaction mixture
2. additionwas added
3. extractionextracted with EtOAc (3×1.0 L)
4. dry with materialThe combined organics was dried over anhydrous Na2SO4
5. concentrationconcentrated under reduced pressure
6. customThe crude (55.0 g, 92%) was carried forward to the next step without further purification