HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 447082Generated: October 30, 2026
Sodium Carbonate → HCID 67179448, compound
https://huagongshe.com/reaction/447082
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Methyl 5-chloropyrazine-2-carboxylate | HCID 406081 | — |
| Reactant | tert-Butyl (2R)-2-methylpiperazine-1-carboxylate | HCID 10262201 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67179448 | HCID 67179448 | — |
Reaction Steps
To (R)-1-boc-methylpiperazine (1 g, 5.0 mmol) in DMF (20 mL) is added 5-chloro-pyrazine-2-carboxylic acid methyl ester (862 mg, 5.0 mmol) and Na2CO3 (2.1 g, 20.0 mmol). The reaction mixture is stirred in a microwave reactor at 140° C. for 3 h. Then the mixture is cooled to rt and the organic solvent is removed in vacuo to afford a brown colored solid as product (1.7 g, quant.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08481542B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-abdf0cb682434953b2b48997f6b4c259 |
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| Source note | uspto-grants-2013_07 |
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