Benzyltrimethylammoniumtribromide → HCID 86654764, compound

Participants

Reaction Steps

A solution of (R)—N-(2-(3-(4-methoxyphenyl)thioureido)ethyl)-2-(2,2,2-trifluoroacetamido)butanamide (412.5 mgs, 1.0 mmol) in methylene chloride (10 mL) was treated with benzyltrimethylammonium tribromide (389.4 mgs 1.00 mmol) and the resulting mixture stirred overnight. The reaction was then quenched with aqueous sodium bicarbonate and extracted into methylene chloride. The organic layer was dried over sodium sulfate, then filtered and concentrated to yield a residue which was purified by normal phase column chromatography, eluting with 5% methanol in chloroform to yield (S)—N-(2-(6-methoxybenzo[d]thiazol-2-ylamino)ethyl)-2-(2,2,2-trifluoroacetamido)-butanamide as a yellow solid.

Provenance & Evidence