Hydrochloric Acid → HCID 67236086, compound

Participants

Reaction Steps

The (S)-tert-butyl 1-(4-(6-(3,4-dimethoxyphenylcarbamoyl)benzo[d]thiazol-2-yl)piperazin-1-yl)-1-oxobutan-2-ylcarbamate (142.8 mg, 0.245 mmol) was dissolved in p-dioxane (3 mL), treated with 4N hydrogen chloride in 1,4-dioxane (3 mL, 12.0 mmol) and the resulting mixture was stirred at room temperature for 5.5 h. The resulting heterogenous mixture was concentrated under high vacuum, then covered with diethyl ether and placed under high vacuum for 2 d to yield the title compound as a pale yellow powder.

Provenance & Evidence