HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → HCID 67236140, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | Ethyl 2-bromo-6-benzothiazolecarboxylate | HCID 12067225 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67236140 | HCID 67236140 | — |
Reaction Steps
The ethyl 2-bromobenzo[d]thiazole-6-carboxylate (11.1 g), BOC-piperazine (9.03 g), potassium carbonate (11.7 g) and acetonitrile (400 mL) were combined and heated to reflux overnight. The resulting mixture was cooled to room temperature, diluted with water and extracted with EtOAc. The organics were concentrated to a yellow solid, which was recrystallized from EtOAc/heptane to yield a ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)benzo[d]thiazole-6-carboxylate as a white powder, which was collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481547B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-8e2213134dff4b08987d2115cf97cac5 |
| Source note | uspto-grants-2013_07 |