Hydrochloric Acid → HCID 58318231, compound

Participants

Reaction Steps

The (S)-tert-butyl 1-(4-(6-(hydroxymethyl)benzo[d]thiazol-2-yl)piperazin-1-yl)-1-oxo-3-(thiophen-2-yl)propan-2-ylcarbamate (83 mg) was dissolved in dry 1,4-dioxane (3 mL) and HCl (4N in 1,4-dioxane, 1 mL) was added. The resulting solution was stirred overnight at room temperature, then concentrated to a white solid. The solid was chromatographed (94.5:5:0.5 dichloromethane:methanol:ammonium hydroxide) to yield the title compound as a colorless oil, which was added to HCl/ether to yield (S)-2-amino-1-(4-(6-(hydroxymethyl)benzo[d]thiazol-2-yl)piperazin-1-yl)-3-(thiophen-2-yl)propan-1-one as a white precipitate, which was collected by filtration.

Provenance & Evidence