Potassium Carbonate → HCID 67235968, compound

Participants

Reaction Conditions

Reaction Steps

(S)-tert-Butyl 1-(4-(6-bromobenzo[d]thiazol-2-yl)piperazin-1-yl)-1-oxo-3-(thiophen-2-yl)propan-2-ylcarbamate (80 mg), 4-(trifluoromethyl)phenylboronic acid (33 mg), palladium tetrakistriphenylphosphine (8 mg), and potassium carbonate (54 mg) were combined in 1,4-dioxane (5 mL) and water (1 mL). The resulting mixture was heated to 95° C. overnight, then diluted with brine, extracted with DCM, concentrated, and chromatographed (100% DCM) to yield (S)-tert-butyl 1-oxo-3-(thiophen-2-yl)-1-(4-(6-(4-(trifluoromethyl)phenyl)benzo[d]thiazol-2-yl)piperazin-1-yl)propan-2-ylcarbamate as a colorless oil (96 mg).

Provenance & Evidence