HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-Ethynyl-1-(4-fluorophenyl)-2-methyl-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Phosphonic acid, dimethyl ester | HCID 13361 | — |
| Reactant | 1-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde | HCID 85997993 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Ethynyl-1-(4-fluorophenyl)-2-methyl-1H-imidazole | HCID 11665595 | — |
Reaction Steps
Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester is dissolved in methanol. Potassium carbonate is added. A solution of 1-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde in methanol is added dropwise at room temperature. The reaction mixture is stirred at room temperature overnight. The desired compound 4-ethynyl-1-(4-fluoro-phenyl)-2-methyl-1H-imidazole is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08481548B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-2f1b4f744d2248d684a24dff5e47aa12 |
| Source note | uspto-grants-2013_07 |