HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethoxyacetyl chloride → 4-{[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]methyl}tetrahydro-2H-pyran-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethoxyacetyl chloride | HCID 84189 | — |
| Reactant | 4-[(3-Aminoquinolin-4-ylamino)methyl]tetrahydropyran-4-ol | HCID 57457824 | — |
| Product | 4-{[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]methyl}tetrahydro-2H-pyran-4-ol | HCID 57515396 | 80.2% |
Reaction Steps
4-{[(3-Aminoquinolin-4-yl)amino]methyl}tetrahydro-2H-pyran-4-ol (7.50 g, 27.4 mmol) was reacted with ethoxyacetyl chloride (3.70 g, 30.1 mmol) and the resulting product was cyclized according to the method described in Part E of Example 9 to provide 4-{[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]methyl}tetrahydro-2H-pyran-4-ol as pale tan crystals (7.50 g, 76%) after crystallization from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541438B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-0d76c944072443cbbdca7e2d326b6acd |
| Source note | uspto-grants-2013_09 |