Fumaric Acid → HCID 86595310, compound

HRID 447187Notes

Reaction equation

HRID 447187 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][Si](C)(C)C)[CH:5]=[CH:4][N:3]=1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH:25]=[C:24](I)[N:23]=[C:22]2[CH:27]([CH3:29])[CH3:28])=[CH:17][CH:16]=1.[C:30]([OH:37])(=[O:36])/[CH:31]=[CH:32]/[C:33]([OH:35])=[O:34]>CO>[C:30]([OH:37])(=[O:36])/[CH:31]=[CH:32]/[C:33]([OH:35])=[O:34].[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:24]2[N:23]=[C:22]([CH:27]([CH3:29])[CH3:28])[N:21]([C:18]3[CH:19]=[CH:20][C:15]([F:14])=[CH:16][CH:17]=3)[CH:25]=2)[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 444972Fumaric AcidHCID 219853912-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridineHCID 673041751-(4-fluoro-phenyl)-4-iodo-2-isopropyl-1H-imidazole

Product 1

HCID 86595310HCID 86595310, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound, MS: m/e=340.1 (M+H+), was prepared in accordance with the general method of example B, step 2, from 2-chloro-4-trimethylsilanylethynyl-pyridine and 1-(4-fluoro-phenyl)-4-iodo-2-isopropyl-1H-imidazole and crystallization from methanol and 1.05 eq fumaric acid.

Sources & evidence

ORD record
ord-f5343fcbbb2a489db54c34e4d4af8de5
Source dataset
uspto-grants-2013_07
Patent number
US08481548B2

Reaction notes

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