2-Chloro-5-fluoropyrimidine → HCID 24963715, compound

HRID 447205Notes

Reaction equation

HRID 447205 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.Cl[C:17]1[N:22]=[CH:21][C:20]([F:23])=[CH:19][N:18]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[N:13]([C:17]3[N:22]=[CH:21][C:20]([F:23])=[CH:19][N:18]=3)[CH:14]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 5834662-Chloro-5-fluoropyrimidineHCID 178418879HCID 178418879, compound

Product 1

HCID 24963715HCID 24963715, compound

Procedure

The title compound, MS: m/e=314.5 (M+H+), was prepared in accordance with the general method of example 3 from 2-chloro-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 2-chloro-5-fluoro-pyrimidine.

Sources & evidence

ORD record
ord-379254fb6b6b4220afd6308ecd7cd2ad
Source dataset
uspto-grants-2013_07
Patent number
US08481548B2

Reaction notes

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