反应详情

温度

80 °C

In a 3 neck flask fitted with a nitrogen inlet, thermometer, and a mechanical stirrer, 4-[2-hydroxy-1-methoxycarbonyl-2-(2-nitro-phenyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester (9.93 g, 24.3 mmoles) was dissolved in acetic acid (1.75 moles, 100 mL). Iron powder (8.90 g, 159 mmoles) was added to the vessel with stirring. The stirred mixture was slowly heated to 80° C. for 30 min and then cooled to room temperature. It was then diluted with ethyl acetate and filtered through a pad of celite. Solids were washed with 20% methanol/ethyl acetate, and then with methanol. The filtrate was concentrated and the residue partitioned between ethyl acetate and aqueous sodium bicarbonate. The layers were separated. The resulting aqueous phase was extracted twice with ethyl acetate. The organic layers were combined. The mixture was washed twice with water and the aqueous phase was discarded. The material was dried (magnesium sulfate) filtered, and concentrated to dryness. Silica gel chromatography afforded the title compound as light yellow foam in 77% yield. MS m/e (M−H)−=345.1.

1. customIn a 3 neck flask fitted with a nitrogen inlet
2. temperaturecooled to room temperature
3. filtrationfiltered through a pad of celite
4. washSolids were washed with 20% methanol/ethyl acetate
5. concentrationThe filtrate was concentrated
6. customthe residue partitioned between ethyl acetate and aqueous sodium bicarbonate
7. customThe layers were separated
8. extractionThe resulting aqueous phase was extracted twice with ethyl acetate
9. washThe mixture was washed twice with water
10. dry with materialThe material was dried (magnesium sulfate)
11. filtrationfiltered
12. concentrationconcentrated to dryness