N-Methyloxindole → HCID 178481470, compound

HRID 447396Notes

Reaction equation

HRID 447396 reaction equation
N1C2C(=CC(/C=C3/C(=O)NC4C/3=CC=CC=4)=CC=2)C=N1.[I:21][C:22]1[C:30]2[C:25](=[CH:26][C:27]([CH:31]=O)=[CH:28][CH:29]=2)[NH:24][N:23]=1.[CH3:33][N:34]1[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:36][C:35]1=[O:43]>>[I:21][C:22]1[C:30]2[C:25](=[CH:26][C:27](/[CH:31]=[C:36]3/[C:35](=[O:43])[N:34]([CH3:33])[C:42]4[C:37]/3=[CH:38][CH:39]=[CH:40][CH:41]=4)=[CH:28][CH:29]=2)[NH:24][N:23]=1

Participants

4

Reactant 3

HCID 6096N-MethyloxindoleHCID 178517063HCID 178517063, compoundHCID 178519327HCID 178519327, compound

Product 1

HCID 178481470HCID 178481470, compound

Procedure

The title compound was synthesized according to the method described for (E)-3-((1H-indazol-5-yl)methylene)indolin-2-one, except substituting 3-iodo-1H-indazole-6-carbaldehyde (462 mg, 1.70 mmol) and 1-methylindolin-2-one (250 mg, 1.70 mmol), the title compound was obtained as a yellow-orange solid (545 mg, 80%); MS ESI 402.2 [M+H]+, calcd for [C17H12IN3O+H]+ 402.01.

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-c2e2f5803a7041f9baa030088a273710
Source dataset
uspto-grants-2013_07
Patent number
US08481533B2

Reaction notes

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