反应详情

To a mixture of 3-formyl-1H-indazole-6-carbonitrile (1.14 g, 6.67 mmol) and 4-picoline (2 mL) was added acetic anhydride (2 mL). The resulting mixture was stirred to make a homogeneous solution and then irradiated 10 min at 100° C. by microwave. After cooling to rt, the mixture was poured onto ice/H2O (50 mL) and stirred for 10 min, sonicated for 2 min, then stirred for 10 min and suction filtered to give the crude (E)-1-acetyl-3-(2-(pyridin-4-yl)vinyl)-1H-indazole-6-carbonitrile as a dark brown solid.

1. customirradiated 10 min at 100° C. by microwave
2. additionthe mixture was poured onto ice/H2O (50 mL)
3. stirringstirred for 10 min
4. customsonicated for 2 min
5. stirringstirred for 10 min
6. filtrationsuction filtered