Acetone Cyanohydrin → 2-Methyl-2-(morpholin-4-yl)propanenitrile

HRID 447536Notes

Reaction equation

HRID 447536 reaction equation
[CH3:1][C:2]([CH3:6])(O)[C:3]#[N:4].[NH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1>CC(C)=O>[CH3:1][C:2]([N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1)([CH3:6])[C:3]#[N:4]

Participants

4

Reactant 2

HCID 6406Acetone CyanohydrinHCID 8083Morpholine

Product 1

HCID 24237842-Methyl-2-(morpholin-4-yl)propanenitrile

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Acetone cyanohydrin (4.3 g, 50 mmol) was dissolved into acetone (5 mL). Morpholine (4.3 g, 50 mmol) was added and the solution was stirred at rt for 24 h. The volatile solvents were removed in vacuo to give the title compound as a clear liquid in quantitative yield. MS ESI 155.0 [M+H]+, calcd for [CsH14N20+H]+ 155.1.

Workup

  1. customThe volatile solvents were removed in vacuo

Sources & evidence

ORD record
ord-c2804d379eef428291abeec2ad2288b5
Source dataset
uspto-grants-2013_07
Patent number
US08481525B2

Reaction notes

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