反应详情

温度

200 °C

A mixture of (1S,2R,4R)-4-[(6-chloropyrimidin-4-yl)amino]-2-(hydroxymethyl)cyclopentanol (500. mg, 2.05 mmol), 1-butanol (4.00 mL) and (S)-(+)-1-aminoindan (0.806 mL, 6.16 mmol) was heated to 200° C. for 90 min in a sealed tube using MWI. The mixture was concentrated in vacuo and purified via silica gel chromatography eluting with a gradient of 5 to 25% MeOH in DCM to afford the title compound as an amorphous solid (513 mg, 73%). LC/MS: Rt=1.20 min, ES+ 341 (AA standard).

1. concentrationThe mixture was concentrated in vacuo
2. custompurified via silica gel chromatography
3. washeluting with a gradient of 5 to 25% MeOH in DCM