HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethoxyacetyl chloride → 2-ethoxy-N-{4-[2-(1-hydroxycyclopropyl)ethylamino]quinolin-3-yl}acetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethoxyacetyl chloride | HCID 84189 | — |
| Reactant | HCID 57457830 | HCID 57457830 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-ethoxy-N-{4-[2-(1-hydroxycyclopropyl)ethylamino]quinolin-3-yl}acetamide hydrochloride | HCID 57515489 | — |
Reaction Conditions
| Temperature | 2.5 °C |
|---|
Reaction Steps
Ethoxyacetyl chloride (0.43 mL) was added to a cooled (0° C.) solution of 1-[2-(3-aminoquinolin-4-ylamino)ethyl]cyclopropanol (3.85 mmol) in dichloromethane (16 mL). The reaction mixture was stirred at 0-5° C. for 60 minutes and then concentrated under reduced pressure to provide crude 2-ethoxy-N-{4-[2-(1-hydroxycyclopropyl)ethylamino]quinolin-3-yl}acetamide hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541438B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-fab3ae9a87a840b397ec4ea1c78c675a |
| Source note | uspto-grants-2013_09 |