Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl orthopropionate → 1-[(4-Amino-2-propyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]cyclopropanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl orthopropionate | HCID 66995 | — |
| 반응물 | 1,1,1-Trimethoxybutane | HCID 123512 | — |
| 반응물 | 4-Chloro-3-nitroquinoline | HCID 11275808 | — |
| 반응물 | 4-Chloro-3-nitronaphthyridine | HCID 12543213 | — |
| 반응물 | 1-(Aminomethyl)cyclopropan-1-ol | HCID 12609623 | — |
| 반응물 | 1-(2-Aminoethyl)cyclopropanol | HCID 55285781 | — |
| 생성물 | 1-[(4-Amino-2-propyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]cyclopropanol | HCID 57515495 | — |
반응 단계
1-[(4-Amino-2-propyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]cyclopropanol was prepared according to the general methods of Parts D through G of Example 84 using 1-(aminomethyl)cyclopropanol in lieu of 1-(2-aminoethyl)cyclopropanol in Part D, 4-chloro-3-nitronaphthyridine in lieu of 4-chloro-3-nitroquinoline in Part D, and trimethyl orthobutyrate in lieu of triethyl orthopropionate in Part F. The crude product was triturated with hot acetonitrile to provide a tan solid. Which was recrystallized from chloroform and hexanes and dried at 140° C. under vacuum to provide product as an off-white solid, mp 199-200° C. MS (ESI) m/z 298 (M+H)+; Anal. calcd for C16H19N5O: C, 64.63; H, 6.44; N, 23.55. Found: C, 64.32; H, 6.62; N, 23.67.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541438B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-63b69e7bbeda44119ec322bdaa6cb786 |
| 출처 메모 | uspto-grants-2013_09 |