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HRID447623

反应详情

EQUATION

反应方程式

HRID 447623 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：CO[C@H]1Cc2ccccc2[C@H]1N
HCID28109796

未命名化合物

结构：CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@@H](Nc2cc(Cl)ncn2)C[C@@H]1O[Si](C)(C)C(C)(C)C
HCID86618716

未命名化合物

PRODUCTS

生成物

1
结构：CO[C@H]1Cc2ccccc2[C@H]1Nc1cc(N[C@@H]2C[C@@H](CO[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)C2)ncn1
HCID66797839

未命名化合物

收率 46%

CONDITIONS

反应条件

温度
180 °C

PROCEDURE

实验过程

A mixture of N-[(1R,3S,4S)-3-{[tert-butyl(dimethyl)silyl]oxy}-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclopentyl]-6-chloropyrimidin-4-amine (0.114 g, 2.42 mmol), (1R,2S)-2-methoxyindan-1-amine (0.170 g, 1.04 mmol) and Na2CO3 (0.10 g, 0.97 mmol) was heated to 180° C. for 2 h in a sealed tube using an oil bath. The reaction was cooled and filtered. The filtrate was concentrated in vacuo. The residue was purified by flash chromatography (50 to 60% EtOAc/hexanes) to afford the title compound as a beige foam (0.066 g, 46%). LC/MS: Rt=2.20 min, ES+ 599 (Formic Acid).

WORKUP

后处理

  1. temperatureThe reaction was cooled
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated in vacuo
  4. customThe residue was purified by flash chromatography (50 to 60% EtOAc/hexanes)